SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL AND TOXICOLOGICAL STUDIES OF HETEROLEPTIC ACETYLSALICYLIC ACID AND ANTHRANILIC ACID METAL COMPLEXES

Authors

  • Mercy. O. Bamigboye Department of Industrial Chemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria
  • Ikechukwu Peter Ejidike Department of Chemistry, University of Fort Hare, P.B. X1314, Alice 5700, South Africa
  • Wahab A. Osunniran Department of Chemistry and Industrial Chemistry, Kwara State University, P.M.B. 1530, Malete, Nigeria
  • Juliana B. Adetunji Department of Biochemistry, Osun State University, P.M.B. 4494, Oshogbo, Nigeria 6Department of Chemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria
  • Joshua A. Obaleye Department of Chemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria
  • Catherine A. Adenipekun Department of Industrial Chemistry, University of Ilorin, P.M.B. 1515, Ilorin, Nigeria

DOI:

https://doi.org/10.4314/jfas.1261

Keywords:

Antibacterial, Toxicology, Analgesics, Anthranilic acid, Acetylsalicylic acid

Abstract

This present study aims to evaluate the antibacterial, analgesic, and toxicological activities of new metals [Ni(II), Cu(II), Cd(II), and Zn(II)] complexes derived from acetylsalicylic acid and anthranilic acid via refluxing method in a 1:1:1 stoichiometry ratio. Characterization was executed using melting point, molar conductance, infrared and ultraviolet-visible spectroscopies. The antibacterial activities were investigated by the agar well diffusion method. The toxicological effect of the test compounds in serum and kidney homogenates of Wister rats was investigated. The screened complexes showed better antibacterial activities than their free ligands. The result of the analysis indicated that acetylsalicylic acid possessed a good significant analgesic activity, while toxicological studies confirmed that the complexes were toxic at the level of administered dosage.

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References

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Published

2023-01-02

How to Cite

BAMIGBOYE, M. O. .; EJIDIKE, I. P.; OSUNNIRAN, W. A. .; ADETUNJI, J. B. .; OBALEYE, J. A. .; ADENIPEKUN, C. A. . SYNTHESIS, CHARACTERIZATION, ANTIBACTERIAL AND TOXICOLOGICAL STUDIES OF HETEROLEPTIC ACETYLSALICYLIC ACID AND ANTHRANILIC ACID METAL COMPLEXES. Journal of Fundamental and Applied Sciences, [S. l.], v. 15, n. 1, p. 62–82, 2023. DOI: 10.4314/jfas.1261. Disponível em: https://jfas.info/index.php/JFAS/article/view/1261. Acesso em: 29 jan. 2023.

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