MOLECULAR BASIS OF OUR ORGANISM’S INTOLERANCE TO LACK OF GENETIC MATERIAL
DOI:
https://doi.org/10.4314/jfas.v13i2.5Keywords:
lack; genetic material; deletion; autosomal monosomy; serious consequences; intolerance.Abstract
Chromosomal fragments deletions are very harmful. They are almost lethal even in the presence of a normal homologue. Autosomal monosomies are incompatible with survival. However, micro-deletions are less fatal but they often produce clinical syndromes With characteristic phenotypes. Thus, a question rises: why does our organism not tolerate the lack of genetic material ? The present work, is a profound investigation on the molecular basis of the intolerance of our organism to the lack of genetic material. The subject under discussion has never been dealt with before. Up to now, no article had been published on this matter.
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[6] Acuna-Hidalgo R., Veltman J. A., et Hoischen A., Genome. Biol. 2016, 17 (1), 241, doi: 10.1186/s13059-016-1110-1.
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[8] O’Roak B.J., Deriziotis P., Lee C., Vives L. et al., Nat. Genet. 2011, 43 (6), 585–9, doi: 10.1038/ng.835.
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[11] De Ligt J., Willemsen M.H., van Bon B.W., Kleefstra T., et al., N. Engl. J. Med. 2012, 367 (20), ,1921–9, doi: 10.1056/NEJMoa1206524.
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[14] Deutschbauer A.M., Jaramillo D.F., Proctor M., Kumm J., et al., Genetics. 2005, 169 (4), 1915-25, doi.org/10.1534/genetics.104.036871.
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[18] Heard P.L., Carter E.M., Crandall A.C., Sebold C., et al., Am. J. Med. Genet. A. 2009, 149A (7), 1431–1437, doi: 10.1002/ajmg.a.32900.
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[22] Papp B., Pal C., et Hurst L.D., Nature. 2003, 424(6945), 194–197, doi: 10.1038/nature01771.
[23] Abruzzi K.C., Smith A., Chen W., et Solomon F., Mol. Cell. Biol 2002, 22(1), 138-47. doi: 10.1128/MCB.22.1.138-147.2002.
[24] Henckel A., et Feil R., Med. Sci. 2008, 24 (8-9), 747–752, doi.org/10.1051/medsci/20082489747.
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[29] Constância M.., Hemberger M.., Hughes J., Dean W., et al., Nature. 2002, 417 (6892), 945-948. doi: 10.1038/nature00819.
[30] Barton SC, Ferguson-Smith AC, Fundele R, Surani A. Influence of paternally imprinted genes on development. Development., 1991, 113(2) :679-88.
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Published
2021-01-10
How to Cite
BOUMENDJEL, S. MOLECULAR BASIS OF OUR ORGANISM’S INTOLERANCE TO LACK OF GENETIC MATERIAL. Journal of Fundamental and Applied Sciences, [S. l.], v. 13, n. 2, p. 708–723, 2021. DOI: 10.4314/jfas.v13i2.5. Disponível em: https://jfas.info/index.php/JFAS/article/view/1049. Acesso em: 30 jan. 2025.
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