ANTIOXIDANT, ANTIDIABETIC AND ANTIBACTERIAL ACTIVITIES OF RICINUS COMMUNIS ROOT EXTRACTS
DOI:
https://doi.org/10.4314/jfas.v11i2.7Keywords:
Antiglycation; Alpha amylase; E.coli; Staphylococcus aureusAbstract
Present study investigated antioxidant, antidiabetic and antibacterial effectiveness of Ricinus communis root. Total phenols content (TPC), total flavonoid contents (TFC) and antioxidant activity were determined by folin-ciocalteu reagent method, aluminium chloride colorimetric technique and 2, 2-diphenyl l- picrylhydrazyl (DPPH) scavenging assay respectively. Antiglycation, alpha amylase inhibition, and antibacterial analyses were done by prescribed procedures. Methanol fraction had significant (P<0.05) TPC (90± 0.19 mg/g GAE) and TFC (32 ± 0.85 µg/mL CE) along with significant (P<0.05) antioxidant activities (41-42%). Extracts presented optimal antidiabetic and antimicrobial efficacies validating therapeutic properties of R.communis root.
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References
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[2] Nithya R S, Anuja M M, Swathy S S, Rajmanickam C, Indra M. J. Hazard. Mater., 2011,187, 386-392, doi: 10.1016/j.jhazmat.2011.01.039.
[3] Jena J, Gupta A K. Ricinus communis -A phytopharmacological review. Int. J. Pharma. Pharmaceutical Sci., 2012, 4, 975-991.
[4] Demiray S, Pintado M E, Castro P M L. Evaluation of phenolic profiles and antioxidant activities of Turkish medicinal plants: Tilia argentena, Crataegi folium leaves and Polygonum bistorta roots. World Acad. Sci. Eng. Technol., 2009, 3, 312-322.
[5] Naseer R, Sultana B, Anwar F, Mehmood Z, Mushtaq M. Variations in phenolics, antioxidant and antifungal activities among different parts of selected medicinal plants. Pak. J. Bot., 2014, 42(2), 706-712.
[6] Babu P R, Bhuvaneswar C, Sandeep G, Ramaiah C V, Rajendra W. Biomed Pharmacother., 2017, 88, 658-666, doi: 10.1016/j.biopha.2017.01.073.
[7] Al-Mamun M A, Akhter Z, Uddin M J, Ferdaus K M, Hoque K M, Ferdousi Z, Reza M A. BMC Complement Altern Med., 2016, 16, 211, doi:10.1186/s12906-016-1185-y.
[8] Jyothi K U, Jayaraj M, Subburaj K S, Prasad K J, Kumudu I, Lakshami V, Reddy B M. Association of TCF7L2 gene polymorphism with T2DM in the population of Hyderabad. PLOS One., 2013, 8(4), 77-84.
[9] Oshaghi E A, Khodadadi I, Mirzaei F, Khazaei M, Tavilani H, Goodarzi M T. J Pharma., 2017, 6081374. doi:10.1155/2017/6081374.
[10] Bayaso I, Nahunnaro H, Gwaray DM. Effects of aqueous extracts of Ricinus communis on radial growth of Alternaria solani. Afr. J. Agri. Res., 2013, 8(36), 4541-4545.
[11] Rao N, Mittal S, Sudhaanshu, Menghaani E. Assessment of phytochemical screening, antioxidant and antibacterial potential of methanolic extracts of the Ricinus communis. Asia J. Pharm. Tech., 2013, 3(1), 20-25.
[12] Rehmati H, Slehi S, Malekpour A, Farhangi F. Antimicrobial activity of castor oil plant (Ricinus communis) seeds extract against gram positive bacteria, gram negative bacteria and yeast. Int. J. Mol. Med. Adv. Sci., 2015, 11, 9-12.
[13] Nasir M, Muhammad Z, Komal R, Nasir R, Muhammad S, Viqaruddin A. Antioxidant, antimicrobial and phytochemical analysis of Cichorium intybus seeds extracts and various organic fractions. Iran J. Pharm. Res., 2012, 11(4), 1145-1151.
[14] Chahardehi A M, Ibrahim D, Suleman S F. Antioxidant activity and polyphenolic contents of some medicinal plants in Urticaceaae family. J. Bio. Sci., 2009, 3, 25-29.
[15] Siddique N A, Mujeeb M, Najmi A K, Akram M. Evaluation of antioxidant activity, quantitative estimation of phenols and flavonoids in different parts of Aegle marmelos. Afr. J. Plant Sci., 2010, 4(1), 001-005.
[16] a) Souri E G, Amin G, Farsan H, Jalalizadeeh H, Barezi S. Screening of thirteen medicinal plants extracts for antioxidant activity. Iran J. Pharm. Res., 2008, 7, 149-154.b) Lanez T and Henni M. Spectrophotometrical study of antioxidant standards interacting with 2,2-diphenyl-1-picrylhydrazyl radical. Chemistry & Chemical Technology, 2016, 10) (3), 255-258. c) Lanez T. et al. Determination of binding parameters of 2-(ferrocenylmethylamino)-benzonitrile and 3-(ferrocenylmethylamino)-benzonitrile with 1,1-diphenyl-2-picrylhydrazyl free radical, J. Fundam. Appl. Sci., 2016, 8(1), 176-181.
[17] Matsuda H, Wang T, Managi H, Yoshikawa M. Structural requirements of flavonoids for inhibition of protein glycation and radical scavenging activities. Bio. Org. Med. Chem., 2003, 11(24), 5317-5323.
[18] Apostolidis E, Kwon Y, Shetty K. Potential of cranberry based herbal synergies for diabetes and hypertension management. Asia Pac. J. Clin. Nutr., 2006, 15(3), 433-441.
[19] Gulfraz M, Imran M, Khadam S, Ahmed D, Asad M J, Abassi K S, Irfan M, Mehmood S. A comparative study of antimicrobial and antioxidant activities of garlic (Allium sativum L.) extracts in various localities of Pakistan. Afr. J. Plant Sci., 2014, 8(6), 298-306.
[20] Yadav R N S, Agarwala M. Phytochemical analysis of some medicinal plants. J. Phytol., 2011, 3(12).
[21] Ilavarasan R, Mallika M, Venkataraman S. Anti-inflammatory and free radical scavenging activity of Ricinus communis root extract. J. Ethnopharmacol., 2006, 103(3), 478-480.
[22] Shokeen P, Anand P, Murali Y K, Tandon V. Food Chem. Toxicol., 2008, 46, 3458-3466, doi: 10.1016/j.fct.2008.08.020.
[23] Verma S K, Yousaf S, Singh S K, Parsad G B K S, Dua V K. Antimicrobial potential of roots of Ricinus communis against pathogenic microorganisms. Int. J. Pharma. Biol Sci., 2011, 1(2), 545-548.
Sharma M, Mir M I, Malla M Y, Mir A H, Bhatt S H, Nazir S, Tripathi J. Antimicrobial potential of various extracts of Ricinus communis. J. Nat. Prod. Plant Resour., 2013, 3, 72-75.
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Published
2019-04-02
How to Cite
HUSSAIN, F.; AHMED, F. ANTIOXIDANT, ANTIDIABETIC AND ANTIBACTERIAL ACTIVITIES OF RICINUS COMMUNIS ROOT EXTRACTS. Journal of Fundamental and Applied Sciences, [S. l.], v. 11, n. 2, p. 651–662, 2019. DOI: 10.4314/jfas.v11i2.7. Disponível em: https://jfas.info/index.php/JFAS/article/view/136. Acesso em: 30 jan. 2025.
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